Usually, yes. The most common culprits — a blown air line, a leaking brake chamber, a failed dryer cartridge, a stuck purge valve, or a rotted gladhand seal — are all standard roadside fixes with parts most mobile mechanics carry. A truck that will not build air is unsafe and often illegal to drive, so this is a stop-and-fix, not a limp-to-town.
Air problems announce themselves two ways: the truck will not build past a certain PSI, or it builds and then bleeds down fast when you shut off. Either way the diagnosis is mostly listening — a mechanic soaps the lines and fittings, checks the chambers, and pulls the dryer cartridge. Chambers, service lines, gladhand seals, dryer cartridges, and most valves are stocked items on a well-run service truck.
Two cautions from the jobs we dispatch. First: if the leak is in a brake chamber, do not cage the spring brake and keep rolling — a caged chamber means no parking brake on that wheel and it is a violation at any inspection. Second: repeated dryer failures usually mean oil is passing from the compressor, and that is worth flagging to your shop before it takes out valves downstream.
Describe what you hear (steady hiss vs. rhythmic puff), where it seems to come from, and what the gauges do. That detail lets the right mechanic bid with the right parts on the truck.